Korpela A, Aarnio P, Sariola H, Törmälä P, Harjula A
Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Finland.
Ann Thorac Surg. 1998 Nov;66(5):1772-6. doi: 10.1016/s0003-4975(98)00763-2.
Treatment of tracheobronchial stenosis is problematic. Conservative methods include stenting the stenotic area, but an ideal stent has not yet been developed. Bioabsorbable airway stents offer benefits; the extraction of the device is unnecessary, and the airway preserves its normal function after stent resorption. The aim of this study was to examine the suitability of self-reinforced poly-L-lactide as a material for an airway stent.
A spiral airway stent made of 0.7-mm wire of self-reinforced poly-L-lactide was implanted operatively in 9 rabbits intratracheally; silicone stents served as controls.
Silicone stents had a tendency to become stenosed with encrustation material and to develop a hyperplastic polyp at both ends. Self-reinforced poly-L-lactide stents were well tolerated and caused no foreign body reaction, and they had a tendency to penetrate into the tracheal wall. They had disappeared at the end of the follow-up of 10 months.
This experimental study showed that bioabsorbable self-reinforced poly-L-lactide is a promising material for an airway stent for treatment of airway stenosis.
气管支气管狭窄的治疗存在问题。保守方法包括对狭窄区域进行支架置入，但尚未开发出理想的支架。可生物吸收的气道支架具有优势；无需取出装置，且支架吸收后气道可保持其正常功能。本研究的目的是检验自增强聚-L-丙交酯作为气道支架材料的适用性。
将由0.7毫米自增强聚-L-丙交酯丝制成的螺旋气道支架经手术植入9只兔的气管内；硅胶支架作为对照。
硅胶支架有被结痂物质阻塞并在两端形成增生性息肉的趋势。自增强聚-L-丙交酯支架耐受性良好，未引起异物反应，且有向气管壁内渗透的趋势。在10个月的随访结束时它们已消失。
本实验研究表明，可生物吸收的自增强聚-L-丙交酯是一种用于治疗气道狭窄的气道支架的有前景的材料。
