Lumiaho J, Heino A, Pietiläinen T, Ala-Opas M, Talja M, Välimaa T, Törmälä P
Departments of Surgery and Pathology, Kuopio University Hospital, Kuopio, Finland.
J Urol. 2000 Oct;164(4):1360-3.
The present study was done to evaluate the biocompatibility of a new biodegradable double helical spiral self-reinforced poly-L, D-lactide copolymer (L/D ratio 96/4, SR-PLA96) ureteric stent.
In sixteen dogs, the right ureter was cut transversally, sutured and stented with a 50 mm. long SR-PLA 96 stent. In eight dogs, left ureter was similarly operated and stented with a double-J pigtail stent (C-Flex, Cook Urological Inc.), while eight remaining ureters served as plain controls. Urine was analyzed for signs of infection. The dogs were terminated at 6, 12 and 24 weeks postoperatively and the ureters dissected to find persistent SR-PLA 96 particles or local ureteric changes. Histologic samples were taken at three levels of dissected ureters in contact with the stent.
C-Flex and SR-PLA 96 materials were well tolerated. Both of these induced only minimal ureteral wall edema, epithelial hyperplasia, epithelial destruction and inflammatory cell reaction. In SR-PLA 96 stented ureters the tissue reaction subsided after the degradation of the device.
SR-PLA 96 spiral stent is regarded highly compatible and SR-PLA 96 might be a suitable material for a partial ureteric stent. Biodegradation of a SR-PLA 96 stent makes stent removal unnecessary.
本研究旨在评估一种新型可生物降解的双螺旋自增强聚左旋、右旋丙交酯共聚物（L/D比例96/4，SR-PLA96）输尿管支架的生物相容性。
在16只犬中，将右侧输尿管横向切断、缝合，并用一根50毫米长的SR-PLA 96支架进行支撑。在8只犬中，左侧输尿管进行类似操作，并用双J猪尾支架（C-Flex，库克泌尿外科公司）进行支撑，而其余8只输尿管作为空白对照。分析尿液中是否有感染迹象。术后6周、12周和24周处死犬，解剖输尿管以寻找残留的SR-PLA 96颗粒或局部输尿管变化。在与支架接触的输尿管的三个解剖层面采集组织学样本。
C-Flex和SR-PLA 96材料耐受性良好。这两种材料仅引起轻微的输尿管壁水肿、上皮增生、上皮破坏和炎症细胞反应。在SR-PLA 96支撑的输尿管中，组织反应在装置降解后消退。
SR-PLA 96螺旋支架被认为具有高度相容性，SR-PLA 96可能是一种适合部分输尿管支架的材料。SR-PLA 96支架的生物降解使得无需取出支架。
