Ling T K, Liu E Y, Cheng A F
Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, PR China.
Chemotherapy. 1999 Jan-Feb;45(1):22-7. doi: 10.1159/000007161.
The susceptibility of 492 Enterobacteriaceae, 227 other gram-negative bacteria, 448 gram-positive bacteria and 108 anaerobic organisms was determined by the agar dilution method against trovafloxacin and other antibiotics. Trovafloxacin was highly active against most of the Enterobacteriaceae including Enterobacter spp. and Citrobacter spp. [minimum inhibitory concentration (MIC)90 <1 mg/l], Acinetobacter spp. and Pseudomonas aeruginosa (MIC90 = 0.25 and 2 mg/l, respectively). The antimicrobial activity was extended to the gram-positive bacteria including streptococci, Streptococcus pneumoniae, coagulase-negative staphylococci and methicillin-sensitive Staphylococcus aureus with MIC90 <1 mg/l. Enterococci and methicillin-resistant S. aureus were inhibited (MIC90 = 2 mg/l; sparfloxacin and ciprofloxacin were 16 and 64 mg/l, respectively). Almost all anaerobic organisms were inhibited by trovafloxacin (MIC90 = 1 mg/l).
采用琼脂稀释法测定了492株肠杆菌科细菌、227株其他革兰氏阴性菌、448株革兰氏阳性菌及108株厌氧菌对曲伐沙星和其他抗生素的敏感性。曲伐沙星对大多数肠杆菌科细菌具有高度活性，包括肠杆菌属和柠檬酸杆菌属（最低抑菌浓度（MIC）90＜1mg/L）、不动杆菌属和铜绿假单胞菌（MIC90分别为0.25mg/L和2mg/L）。其抗菌活性还扩展至革兰氏阳性菌，包括链球菌、肺炎链球菌、凝固酶阴性葡萄球菌和甲氧西林敏感金黄色葡萄球菌，MIC90＜1mg/L。肠球菌和甲氧西林耐药金黄色葡萄球菌受到抑制（MIC90 = 2mg/L；司帕沙星和环丙沙星的MIC90分别为16mg/L和64mg/L）。几乎所有厌氧菌都被曲伐沙星抑制（MIC90 = 1mg/L）。
