黑腹果蝇卵母细胞中的重组时间：来自温度敏感型重组缺陷突变体的证据。
Time of recombination in the Drosophila melanogaster oocyte: evidence from a temperature-sensitive recombination-deficient mutant.
作者信息
Grell R F
出版信息
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3351-4. doi: 10.1073/pnas.75.7.3351.
Abstract
A temperature-sensitive recombination-deficient mutant, rec-126, has been isolated that permits high frequencies of recombination at the permissive temperature (25 degrees) but greatly decreases recombination at the restrictive temperature (31 degrees). The sensitive period for response of female germ cells carrying this mutant to the restrictive temperature has been defined. Sensitivity begins very close to the time the oocyte enters premeiotic interphase and initiates DNA synthesis; it continues for the duration of premeiotic-S; and it terminates with the completion of S. This time span precisely coincides with the sensitive period for enhancement of recombination by heat in the normal genome and is further characterized by the presence of the synaptonemal complex. These results provide compelling evidence for identifying premeiotic-S as the time of meiotic recombination.
摘要
已分离出一种温度敏感型重组缺陷突变体rec-126，它在允许温度（25摄氏度）下允许高频重组，但在限制温度（31摄氏度）下大大降低重组频率。已确定携带这种突变体的雌性生殖细胞对限制温度作出反应的敏感期。敏感性在卵母细胞进入减数分裂前间期并开始DNA合成时就开始了；它在减数分裂前S期持续存在；并在S期完成时终止。这个时间段与正常基因组中热增强重组的敏感期精确重合，并且以联会复合体的存在为进一步特征。这些结果为确定减数分裂前S期为减数分裂重组时间提供了有力证据。
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