黑腹果蝇卵母细胞减数分裂前DNA合成过程中的联会复合体
Synaptonemal complexes during premeiotic DNA synthesis in oocytes of Drosophila melanogaster.
作者信息
Day J W, Grell R F
出版信息
Genetics. 1976 May;83(1):67-79. doi: 10.1093/genetics/83.1.67.
Well-synchronized populations of oocytes obtained by means of the "pupal system" (Grell, 1973a) have been examined to determine the time of appearance of the synaptonemal complex. The complex first appears in the most advanced oocytes between 132 and 138 hr of female development. Between 138 and 156 hr the complex apparently undergoes a fourfold increase in length. At 150 and 156 hr the complex system is extensive and present in virtually all oocytes. Previous studies using the pupal system have placed the period of premeiotic DNA synthesis between 132 and 162 hr. Thus, indirect evidence indicates that a significant portion of synaptonemal complex formation is coextensive with the main DNA replication in the oocyte. Direct evidence that DNA synthesis and complex formation occur simultaneously in oocytes has been obtained by electron microscope autoradiography. By definition, then, the stage of synaptonemal complex formation in Drosophila must include premeiotic interphase.
通过“蛹系统”（格雷尔，1973a）获得的同步良好的卵母细胞群体已被检测，以确定联会复合体出现的时间。该复合体首次出现在雌性发育132至138小时之间最成熟的卵母细胞中。在138至156小时之间，该复合体的长度明显增加了四倍。在150和156小时时，复合体系统广泛存在于几乎所有的卵母细胞中。先前使用蛹系统的研究将减数分裂前DNA合成期定在132至162小时之间。因此，间接证据表明，联会复合体形成的很大一部分与卵母细胞中的主要DNA复制同时发生。通过电子显微镜放射自显影已获得卵母细胞中DNA合成和复合体形成同时发生的直接证据。那么，根据定义，果蝇中联会复合体形成的阶段必须包括减数分裂前的间期。
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