超氧化物歧化酶在缺血性脑损伤中的作用：一项使用SOD-1转基因小鼠的研究。
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
作者信息
Kinouchi H, Kamii H, Mikawa S, Epstein C J, Yoshimoto T, Chan P H
机构信息
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Cell Mol Neurobiol. 1998 Dec;18(6):609-20. doi: 10.1023/a:1020677701368.
Abstract
- Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by its reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cerebral ischemia.
摘要
- 一氧化氮自由基（NO）在局灶性脑缺血的病理生理学中起重要作用。2. 血管中的NO可通过增加脑血流量来减轻缺血性脑损伤，而神经元中的NO可能在脑缺血后介导神经毒性，主要是通过与超氧化物反应生成过氧亚硝酸盐。3. 这些发现可能有助于制定治疗脑缺血的策略。
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本文引用的文献
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