Joelsson I, Gidlund L, Anzén B, Ingelman-Sundberg A
Acta Obstet Gynecol Scand. 1976;55(4):325-31. doi: 10.3109/00016347609158507.
Smooth muscle is capable of responding by contraction to mechanical distension. Neither the structural basis for this phenomenon nor the theories of smooth muscle behavior are completely clear. A method is now described by which the contractile response to mechanical distension of the human uterine muscle in vivo is determined. The distension is enforced sinusoidally within the frequency range 0.005-2 Hz, by filling and emptying a rubber balloon introduced into the uterine cavity. A tonometric index of the myometrium is defined using Hook's law after the approximate evaluation of a contractile modulus and the tangential stress and strain in the inner layer of the uterine wall. The regression line of indices upon frequency is calculated and intercept and regression coefficient of the equation for basic conditions are compared with those obtained during administration of pharmacologically active agents. It is suggested that the differences in intercepts and regression coefficients be used as a measure of drug effect.
平滑肌能够通过收缩对机械扩张作出反应。这一现象的结构基础以及平滑肌行为的理论都尚未完全明确。本文描述了一种测定体内人子宫肌对机械扩张的收缩反应的方法。通过向子宫腔内插入并充放气一个橡胶气球，在0.005 - 2赫兹的频率范围内以正弦方式施加扩张。在大致评估了收缩模量以及子宫壁内层的切向应力和应变后，根据胡克定律定义子宫肌层的张力指数。计算指数随频率变化的回归线，并将基础条件下方程的截距和回归系数与给予药理活性剂期间获得的截距和回归系数进行比较。建议将截距和回归系数的差异用作药物效应的衡量指标。
