D'Amico D, Moschiano F, Leone M, Ariano C, Ciusani E, Erba N, Grazzi L, Ferraris A, Schieroni F, Bussone G
Headache Center, Neurological Institute C. Besta, Milan, Italy.
Cephalalgia. 1998 Nov;18(9):618-21; discussion 591. doi: 10.1046/j.1468-2982.1998.1809618.x.
Migraine, particularly migraine with aura (MA), may be a risk factor for ischemic stroke (IS). The reasons for this association are unknown. We investigated the presence of genetic abnormalities of the protein C system in 83 MA patients, 31 IS patients, and 124 healthy controls, all aged under 45 years. We found an increased frequency of activated protein C resistance due to Arg506Gln factor V mutation, and of protein S deficiency in both disorders, with figures higher than those reported in the general population and significantly different from those found in controls. These prothrombotic genetic abnormalities may be shared risk factors in IS and MA, and may play a role in increasing the risk of cerebrovascular disease in migraineurs.
偏头痛，尤其是伴有先兆的偏头痛（MA），可能是缺血性卒中（IS）的一个危险因素。这种关联的原因尚不清楚。我们调查了83例MA患者、31例IS患者和124例年龄均在45岁以下的健康对照者中蛋白C系统的基因异常情况。我们发现，由于凝血因子V的Arg506Gln突变导致的活化蛋白C抵抗以及两种疾病中蛋白S缺乏的频率增加，这些数字高于一般人群中报道的数字，且与对照组中的数字有显著差异。这些促血栓形成的基因异常可能是IS和MA的共同危险因素，并且可能在增加偏头痛患者脑血管疾病风险中起作用。
