Haan J, Kappelle L J, de Ronde H, Ferrari M D, Bertina R M
Department of Neurology, Leiden University Hospital, The Netherlands.
Cephalalgia. 1997 Aug;17(5):605-7. doi: 10.1046/j.1468-2982.1997.1705605.x.
The etiology of migrainous cerebral infarction is unknown, but may involve prothrombotic coagulation abnormalities. Therefore, we studied resistance to activated protein C and the presence of the Arg506Gln factor V Leiden mutation in 20 patients with migrainous cerebral infarction. Only one heterozygous carrier of the mutation was found, whereas other patients did not carry the mutation. This indicates that the factor V Leiden mutation is not a major risk factor for migrainous cerebral infarction.
偏头痛性脑梗死的病因尚不清楚，但可能涉及血栓前凝血异常。因此，我们研究了20例偏头痛性脑梗死患者对活化蛋白C的抵抗情况以及第506位密码子精氨酸突变为谷氨酰胺的凝血因子V Leiden突变的存在情况。仅发现1例该突变的杂合携带者，而其他患者未携带该突变。这表明凝血因子V Leiden突变并非偏头痛性脑梗死的主要危险因素。
