Donaldson E, Van Nagell J R, Wood E G, Pletsch Q, Goldenberg D M
AJR Am J Roentgenol. 1976 Nov;127(5):829-31. doi: 10.2214/ajr.127.5.829.
Plasma carcinoembryonic antigen (CEA) levels in 75 patients with invasive cervical cancer were measured during and after radiation therapy. Initial CEA levels were elevated in 65% of the patients, the incidence varying with stage of disease. Of the 32 patients followed during therapy, CEA levels rose in 26 (81%). CEA values after therapy in the same 32 patients showed three patterns: (1) decline to normal, associated with a disease-free state; (2) decline but not to normal, associated with heavy cigarette smoking or persistent disease; and (3) decline to normal, followed by a rise to abnormal, associated with tumor recurrence. Elevation of CEA levels preceded recognition of recurrent cervical cancer by as much as 4 months in five of seven patients.
对75例浸润性宫颈癌患者在放疗期间及放疗后测定了血浆癌胚抗原（CEA）水平。65%的患者初始CEA水平升高，其发生率随疾病分期而异。在治疗期间随访的32例患者中，26例（81%）CEA水平升高。同一32例患者治疗后的CEA值呈现三种模式：（1）降至正常，与无病状态相关；（2）下降但未降至正常，与大量吸烟或疾病持续存在相关；（3）降至正常，随后又升至异常，与肿瘤复发相关。在7例患者中的5例中，CEA水平升高比复发性宫颈癌的确诊早达4个月。
