Nagl M, Gottardi W
Institute for Hygiene, Leopold-Franzens University of Innsbruck, Austria.
J Pharm Pharmacol. 1998 Nov;50(11):1317-20. doi: 10.1111/j.2042-7158.1998.tb03351.x.
We have studied the activity of the weak endogenous oxidant N-chlorotaurine against Mycobacterium terrae. The study revealed slow killing of more than 2h duration by 1% (55 mM) N-chlorotaurine. In the presence of ammonium chloride, however, killing times decreased to a few minutes, even by 0.1% N-chlorotaurine. This phenomenon is explained by formation of the lipophilic and therefore more bactericidal monochloramine as a result of transhalogenation of ammonia by N-chlorotaurine.
我们研究了内源性弱氧化剂N-氯代牛磺酸对土地分枝杆菌的活性。研究发现，1%（55 mM）的N-氯代牛磺酸对其有超过2小时的缓慢杀菌作用。然而，在氯化铵存在的情况下，即使是0.1%的N-氯代牛磺酸，杀菌时间也会缩短至几分钟。这种现象可通过N-氯代牛磺酸将氨进行卤素转移反应生成亲脂性更强、因而杀菌性更强的一氯胺来解释。
