Büyükaşik Y, Soylu B, Soylu A R, Ozcebe O I, Canbakan S, Haznedaroğlu I C, Kirazli S, Başer Y, Dündar S V
Dept of Haematology, Hacettepe University Medical School, Ankara, Turkey.
Eur Respir J. 1998 Dec;12(6):1375-9. doi: 10.1183/09031936.98.12061375.
Platelets have been suggested to play a role in the inflammatory response, including defence against bacteria. The aims of this study were to determine in vivo platelet activity during the clinical course of pulmonary tuberculosis and to investigate whether or not there is a correlation between the magnitude of platelet activation and the extent of the pulmonary disease. T-lymphocyte activity was also analysed in the patients. Platelet factor-4 (PF4) and soluble interleukin-2 receptor-alpha (sIL-2Ralpha) concentrations were used as markers of platelet and T-lymphocyte activation, respectively. Twenty-five patients with pulmonary tuberculosis were studied. Fifteen healthy subjects served as a control group. The levels of both sIL-2Ralpha (3,000+/-1,948 pg x mL(-1)) and PF4 (103.1+/-6.7 IU x mL(-1)) were significantly higher in the patients with tuberculosis than in the control group (984+/-360 pg x mL(-1) and 78.2+/-23.9 IU x mL(-1), respectively) (Mann-Whitney U-test, p<0.001 for both comparisons). The plasma PF4 levels were found to be well correlated with the extent of pulmonary lesions on chest radiography (the Spearman's bivariate correlation analysis, r=0.65, p<0.001). However, sIL-2Ralpha concentrations did not correlate with the extent of disease. In conclusion, it has been suggested that platelet and T-lymphocyte activation occurs during pulmonary tuberculosis. The good correlation between platelet activation and the extent of pulmonary tuberculosis might be ascribed to a pathophysiological role of platelets in pulmonary tuberculosis.
血小板已被认为在炎症反应中发挥作用，包括抵御细菌。本研究的目的是确定肺结核临床病程中的体内血小板活性，并调查血小板活化程度与肺部疾病程度之间是否存在相关性。还对患者的T淋巴细胞活性进行了分析。血小板因子4（PF4）和可溶性白细胞介素-2受体α（sIL-2Rα）浓度分别用作血小板和T淋巴细胞活化的标志物。对25例肺结核患者进行了研究。15名健康受试者作为对照组。肺结核患者的sIL-2Rα（3,000±1,948 pg·mL⁻¹）和PF4（103.1±6.7 IU·mL⁻¹）水平均显著高于对照组（分别为984±360 pg·mL⁻¹和78.2±23.9 IU·mL⁻¹）（Mann-Whitney U检验，两项比较p均<0.001）。发现血浆PF4水平与胸部X线片上肺部病变的程度密切相关（Spearman双变量相关分析，r = 0.65，p<0.001）。然而，sIL-2Rα浓度与疾病程度无关。总之，提示在肺结核期间发生血小板和T淋巴细胞活化。血小板活化与肺结核程度之间的良好相关性可能归因于血小板在肺结核中的病理生理作用。
