外源性内分泌因子对5-羟色氨酸诱导的头部抽搐反应的调节作用。

Modification of the 5-hydroxytryptophan-induced head-twitch response by exogenous endocrine agents.

作者信息

Brotherton C S, Doggett N S

出版信息

Psychopharmacology (Berl). 1978 Jul 6;58(2):145-51. doi: 10.1007/BF00426897.

Abstract

Estrogens both alone and in combination with progestagens, gonadotrophins, gonadotrophin-releasing factor, corticosteroids, and corticotrophin antagonise the head-twitch response produced by 5-hydroxytryptophan in mice. In contrast, a potentiation was seen following thyroid hormones, thyrotrophin, and thyrotrophin-releasing hormone. Pre-treatment with androgens had no significant effect. Possible mechanisms for these interactions are discussed.

摘要

雌激素单独使用以及与孕激素、促性腺激素、促性腺激素释放因子、皮质类固醇和促肾上腺皮质激素联合使用时，均可拮抗5-羟色氨酸在小鼠中产生的头部抽搐反应。相比之下，甲状腺激素、促甲状腺激素和促甲状腺激素释放激素可增强该反应。雄激素预处理无显著影响。文中讨论了这些相互作用的可能机制。