长春新碱（硫酸长春新碱）对人源NHIK 3025细胞系的抑制及细胞毒性作用。
Inhibitory and cytotoxic effects of Oncovin (Vincristine sulfate) on cells of human line NHIK 3025.
作者信息
Dahl W N, Oftebro R, Pettersen E O, Brustad T
出版信息
Cancer Res. 1976 Sep;36(9 pt.1):3101-5.
The inhibitory effect of Oncovin (vincristine sulfate) on cell division was studied in human cell line NHIK 3025. Oncovin arrested the cells in metaphase at concentrations as low as 10(-3) mug/ml. At 8 X 10(-3) mug/ml and higher concentrations, the arrest was complete after 6 hr of treatment. The arrest was irreversible after exposure for 6 hr to 16 X 10(-3) mug Oncovin per ml. The X-ray radiosensitivity of aerobic cells of the same line pretreated with 16 X 10(-3) mug Oncovin per ml for 6 hr (Oncovin removed before irradiation) was found to be about equal to that of untreated cells. Even when present during irradiation, Oncovin did not exert any modifying effect on the radiosensitivity of either aerobic or extremely hypoxic cells.
研究了长春新碱（硫酸长春新碱）对人细胞系NHIK 3025细胞分裂的抑制作用。长春新碱在低至10⁻³微克/毫升的浓度下就能使细胞停滞在中期。在8×10⁻³微克/毫升及更高浓度下，处理6小时后停滞完全。每毫升暴露于16×10⁻³微克长春新碱6小时后，这种停滞是不可逆的。发现用每毫升16×10⁻³微克长春新碱预处理6小时（照射前去除长春新碱）的同一细胞系的需氧细胞的X射线放射敏感性与未处理细胞的放射敏感性大致相等。即使在照射期间存在长春新碱，它对需氧细胞或极乏氧细胞的放射敏感性也没有任何修饰作用。
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