Burke W J, Li S W, Schmitt C A, Xia P, Chung H D, Gillespie K N
Department of Neurology, Saint Louis University Medical School, 3635 Vista at Grand, Saint Louis, MO 63110, USA.
Brain Res. 1999 Jan 23;816(2):633-7. doi: 10.1016/s0006-8993(98)01211-6.
3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). NE neurons in the locus ceruleus (LC) die in Alzheimer's disease (AD). To determine if DOPEGAL could contribute to NE neuron death in AD we measured levels of DOPEGAL, NE and their synthesizing enzymes in LC from AD and matched controls. We found 2.8- and 3.6-fold increases in DOPEGAL and MAO-A in AD LC neuronal cell bodies compared to controls. NE and dopamine beta-hydroxylase were increased by 3.8- and 10.7-fold, respectively. Implications for the mechanism of neuron death in AD are discussed.
3,4-二羟基苯乙醇醛（DOPEGAL）是去甲肾上腺素（NE）具有神经毒性的单胺氧化酶A（MAO-A）代谢产物。蓝斑（LC）中的NE神经元在阿尔茨海默病（AD）中会死亡。为了确定DOPEGAL是否会导致AD中NE神经元死亡，我们测量了AD患者和匹配对照组LC中DOPEGAL、NE及其合成酶的水平。我们发现，与对照组相比，AD患者LC神经元细胞体中的DOPEGAL和MAO-A分别增加了2.8倍和3.6倍。NE和多巴胺β-羟化酶分别增加了3.8倍和10.7倍。本文讨论了其对AD中神经元死亡机制的影响。
