Davidson R N
Department of Infection and Tropical Diseases, Lister Unit, Northwick Park Hospital, Harrow, Middlesex, England.
Drugs. 1998 Dec;56(6):1009-18. doi: 10.2165/00003495-199856060-00005.
This article summarises the clinical features of visceral, cutaneous and mucocutaneous leishmaniasis, and leishmaniasis in HIV-coinfected patients. The characteristics and clinical use of pentavalent antimonials and the traditional drugs used in all forms of leishmaniasis are described. There have been important developments in therapy, such as aminosidine (paromomycin) conventional amphotericin B and lipid-associated amphotericin B. In most cases of leishmaniasis there is a range of treatment options which is determined by the geographical and clinical features. This review is intended to assist the clinician in choosing treatment and in using unfamiliar drugs with safety and efficacy.
本文总结了内脏利什曼病、皮肤利什曼病和黏膜皮肤利什曼病以及合并感染HIV患者的利什曼病的临床特征。描述了五价锑化合物以及用于各种形式利什曼病的传统药物的特点和临床应用。治疗方面有了重要进展，如氨苯脒（巴龙霉素）、传统两性霉素B和脂质体两性霉素B。在大多数利什曼病病例中，有一系列治疗选择，这取决于地理和临床特征。本综述旨在帮助临床医生选择治疗方法，并安全有效地使用不熟悉的药物。
