[所谓氯乙烯病的临床表现与病理]
[Clinical picture and pathology of the so-called vinyl chloride disease].
作者信息
Szadkowski D
出版信息
Fortschr Med. 1976 Sep 16;94(26):1412-5.
About 26 years ago symptoms of liver and spleen were described for the first time by Tribukh et al. in laborers exposed to vinyl chloride. Besides these symptoms sclerodermia, acroosteolysis and Raynaud's phaenomenon are known to be typical for the VC disease. Rather high concentrations of VC seem to be necessary to cause this disease. After cessation of exposure the symptoms may improve partly. Haemangiosarcoma of the liver may occur as the most serious effect of prolonged exposure to vinyl chloride. Presently 48 cases induced by VC exposure are observed all over the world. Diagnosis is difficult, the prognosis of this cancer is practically always fatal. The improvement of working places by the chemical industries should further reduce the risk of acquiring VC disease as well as haemangioma of the liver due to VC exposure.
大约26年前，特里布赫等人首次描述了氯乙烯接触工人的肝脏和脾脏症状。除了这些症状外，硬皮病、肢端骨质溶解和雷诺现象也是氯乙烯病的典型症状。似乎需要相当高浓度的氯乙烯才会引发这种疾病。接触停止后，症状可能会部分改善。长期接触氯乙烯最严重的后果可能是发生肝血管肉瘤。目前，全世界共观察到48例由氯乙烯接触诱发的病例。诊断困难，这种癌症的预后几乎总是致命的。化工行业改善工作场所应进一步降低因接触氯乙烯而患上氯乙烯病以及肝血管瘤的风险。
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