由在非洲感染的供体产生的细胞毒性T淋巴细胞对1型人类免疫缺陷病毒非B亚型表位的特异性识别
Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa.
作者信息
Dorrell L, Dong T, Ogg G S, Lister S, McAdam S, Rostron T, Conlon C, McMichael A J, Rowland-Jones S L
机构信息
Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.
出版信息
J Virol. 1999 Feb;73(2):1708-14. doi: 10.1128/JVI.73.2.1708-1714.1999.
Abstract
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.
摘要
我们对三名在东非感染的捐赠者中针对A或C亚型1型人类免疫缺陷病毒（HIV）的细胞毒性T淋巴细胞（CTL）反应进行了详细研究。我们确定了几个新的非B亚型CTL表位，包括一些受非洲人中常见的HLA等位基因限制的表位。虽然确实存在对这些表位的跨亚型CTL识别，但识别也可能具有高度的亚型特异性。
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