女性尿道癌：治疗结果分析及对标准化管理策略的呼吁
Female urethral carcinoma: an analysis of treatment outcome and a plea for a standardized management strategy.
作者信息
Dalbagni G, Zhang Z F, Lacombe L, Herr H W
机构信息
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
出版信息
Br J Urol. 1998 Dec;82(6):835-41. doi: 10.1046/j.1464-410x.1998.00878.x.
OBJECTIVE
To evaluate our experience with primary carcinomas of the female urethra, by analysing the impact of tumour variables and treatment on overall, disease-specific, local recurrence- and metastasis-free survival.
PATIENTS AND METHODS
Between 1958 and 1994, 72 women (median age 60 years, mean 59, range 21-84) with primary urethral carcinoma were identified. They were followed for a median (range) of 85 (0-384) months. The patients were stratified by stage, nodal status, histology, treatment, type of surgery, site of disease, year of diagnosis and smoking habit.
RESULTS
In a univariate analysis, stage, nodal status, type of surgery and site of the disease were important factors for survival and recurrence. In a multivariate analysis, primary stage, nodal status and site of disease were independent predictors of survival.
CONCLUSION
Current modalities of treatment are ineffective for local control and survival; new treatment strategies are needed for female urethral cancers.
目的
通过分析肿瘤变量和治疗对总生存、疾病特异性生存、无局部复发和无转移生存的影响，评估我们在女性尿道原发性癌方面的经验。
患者与方法
1958年至1994年间，确定了72例原发性尿道癌女性患者（中位年龄60岁，平均59岁，范围21 - 84岁）。对她们进行了中位（范围）85（0 - 384）个月的随访。患者按分期、淋巴结状态、组织学、治疗、手术类型、疾病部位、诊断年份和吸烟习惯进行分层。
结果
单因素分析中，分期、淋巴结状态、手术类型和疾病部位是生存和复发的重要因素。多因素分析中，原发分期、淋巴结状态和疾病部位是生存的独立预测因素。
结论
目前的治疗方式对局部控制和生存无效；女性尿道癌需要新的治疗策略。
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