Suppr超能文献

用牛乳铁蛋白对大鼠进行口服治疗可抑制角叉菜胶诱导的炎症;与细胞因子产生减少相关。

Oral treatment of rats with bovine lactoferrin inhibits carrageenan-induced inflammation; correlation with decreased cytokine production.

作者信息

Zimecki M, Miedzybrodzki R, Szymaniec S

机构信息

Institure of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla, Wrocław, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1998;46(6):361-5.

PMID:9883315
Abstract

The aim of this study was to investigate an effect of oral treatment of rats with bovine lactoferrin (BLF) on carrageenan-induced inflammation. Rats were given 5 oral doses of BLF (10 mg each) on alternate days and 24 h after the last dose a carrageenan inflammation was induced in the hind foot. Control rats were given 0.9% natrium chloride (NaCl) or bovine serum albumin (BSA). The magnitude of the reaction was measured after 2 h (optimal response) and expressed as an increase of the foot pad thickness in milimeters. The evaluation of BLF effects on carrageenan reaction was supplemented by determination of the ability of spleen cell cultures to produce interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) upon lipopolysaccharide (LPS) induction using bioassays. The results revealed an inhibition of the carrageenan-induced inflammation in BLF-treated rats by 50 and 40% as compared to NaCl and BSA control groups, respectively. The inhibition was also associated with a substantial decrease in the ability of splenocytes to produce IL-6 in BLF-treated rats (94 and 83% as compared to NaCl- and BSA-treated groups). The LPS-induced TNF-alpha production was also decreased, although to a lesser degree (48 and 35%, respectively). The decreased ability of spleen cells to produce inflammatory cytokines in BLF-treated rats indicates that hyporeactivity of the immune system cells may be the basis for the inhibition of carrageenan-induced inflammation.

摘要

本研究的目的是调查用牛乳铁蛋白(BLF)口服治疗大鼠对角叉菜胶诱导的炎症的影响。大鼠每隔一天口服5剂BLF(每剂10毫克),在最后一剂后24小时,在后足诱导角叉菜胶炎症。对照大鼠给予0.9%氯化钠(NaCl)或牛血清白蛋白(BSA)。在2小时后(最佳反应)测量反应程度,并以足垫厚度增加毫米数表示。通过生物测定法测定脾细胞培养物在脂多糖(LPS)诱导下产生白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)的能力,补充了对BLF对角叉菜胶反应影响的评估。结果显示,与NaCl和BSA对照组相比,BLF治疗的大鼠对角叉菜胶诱导的炎症的抑制率分别为50%和40%。这种抑制还与BLF治疗的大鼠脾细胞产生IL-6的能力大幅下降有关(与NaCl和BSA治疗组相比分别为94%和83%)。LPS诱导的TNF-α产生也有所下降,尽管程度较小(分别为48%和35%)。BLF治疗的大鼠脾细胞产生炎性细胞因子的能力下降表明,免疫系统细胞的反应性降低可能是抑制角叉菜胶诱导炎症的基础。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验