Gladen B C, Longnecker M P, Schecter A J
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Am J Ind Med. 1999 Jan;35(1):15-20. doi: 10.1002/(sici)1097-0274(199901)35:1<15::aid-ajim3>3.0.co;2-z.
Correlations among human levels of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans potentially complicate interpretation of studies of their individual health effects. Outcomes attributed to one may, in fact, be due to another.
We present correlations among dioxins, furans, and PCBs in blood collected in 1991-1992 from 44 American Vietnam veterans from Michigan.
Correlations among specific dioxins and furans ranged from 0.26 to 0.80, with the higher-chlorinated congeners being more highly correlated. Correlations among PCBs ranged from 0.06 to 0.94, with those occurring at highest concentrations being more highly correlated. Correlations of PCBs with dioxins and furans ranged from -0.09 to 0.59. Correlations of individual chemicals with total dioxin toxic equivalents ranged from 0.31 to 0.76.
DISCUSSION/CONCLUSIONS: If confirmed in other populations, such correlations may allow the use of simpler assays but may also raise issues of confounding and calibration.
人体中多氯联苯、多氯二苯并 - 对 - 二噁英和多氯二苯并呋喃水平之间的相关性可能会使对它们各自健康影响的研究解读变得复杂。实际上，归因于一种物质的结果可能是由另一种物质导致的。
我们展示了1991 - 1992年从密歇根州的44名美国越战退伍军人采集的血液中二噁英、呋喃和多氯联苯之间的相关性。
特定二噁英和呋喃之间的相关性范围为0.26至0.80，氯化程度较高的同系物相关性更强。多氯联苯之间的相关性范围为0.06至0.94，浓度最高的那些多氯联苯相关性更强。多氯联苯与二噁英和呋喃的相关性范围为 - 0.09至0.59。单个化学物质与总二噁英毒性当量的相关性范围为0.31至0.76。
讨论/结论：如果在其他人群中得到证实，这种相关性可能允许使用更简单的检测方法，但也可能引发混杂和校准问题。
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