Patrick D L, Martin M L, Bushnell D M, Yalcin I, Wagner T H, Buesching D P
Department of Health Services, University of Washington, Seattle 98195-7660, USA.
Urology. 1999 Jan;53(1):71-6. doi: 10.1016/s0090-4295(98)00454-3.
To report on the further development of the Incontinence Quality of Life Instrument (I-QOL), a self-report quality of life measure specific to urinary incontinence (UI), including its measurement model, responsiveness, and effect size.
Incontinent female patients (141 with stress, 147 with mixed UI) completed the I-QOL and comparative measures at screening, pretreatment, and four subsequent follow-up visits during participation in a multicenter, double-blind, placebo-controlled, randomized trial assessing the efficacy of duloxetine. Psychometric testing followed standardized procedures.
Factor analysis confirmed an overall score and three subscale scores (avoidance and limiting behaviors, psychosocial impacts, and social embarrassment). All scores were internally consistent (alpha = 0.87 to 0.93) and reproducible (ICC = 0.87 to 0.91). The pattern of previously reported correlations with the Short-Form 36-item Health Survey and Psychological Well-Being Schedule were confirmed. Responsiveness statistics using changes in the independent measures of stress test pad weight, number of incontinent episodes, and patient global impression of improvement ranged from 0.4 to 0.8. Minimally important changes ranged from 2% to 5% in association with these measures and effect sizes.
In a clinical trial, the I-QOL proved to be valid, reproducible, and responsive to treatment for UI in women.
报告尿失禁生活质量量表（I-QOL）的进一步发展情况，这是一种针对尿失禁（UI）的自评生活质量测量工具，包括其测量模型、反应性和效应量。
在一项评估度洛西汀疗效的多中心、双盲、安慰剂对照、随机试验中，尿失禁女性患者（141例压力性尿失禁患者、147例混合性尿失禁患者）在筛查、预处理以及参与研究期间随后的四次随访时完成了I-QOL及相关比较测量。心理测量测试遵循标准化程序。
因子分析确定了一个总分和三个子量表分数（回避和限制行为、心理社会影响以及社交尴尬）。所有分数在内部都是一致的（α = 0.87至0.93）且具有可重复性（组内相关系数 = 0.87至0.91）。先前报告的与36项简短健康调查和心理健康状况量表的相关性模式得到了证实。使用压力测试垫重量、尿失禁发作次数和患者总体改善印象等独立测量指标变化的反应性统计范围为0.4至0.8。与这些测量指标和效应量相关的最小重要变化范围为2%至5%。
在一项临床试验中，I-QOL被证明对女性尿失禁的治疗有效、可重复且有反应。
