Oh Seung-June, Ku Ja Hyeon
Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongondong, Jongno-gu, Seoul, 110-744, Korea.
Qual Life Res. 2006 Apr;15(3):493-501. doi: 10.1007/s11136-005-2487-6.
The aim of this study was to determine whether a generic health outcome instrument would be helpful for evaluating women with stress urinary incontinence (UI) combined with or without urge UI.
A total of 109 women with UI and 80 controls participated in the study. Health-related quality of life (QOL) was measured using the Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and the Incontinence Quality of Life (I-QoL) questionnaire.
Among eight domains of the SF-36 questionnaire, only four domains, namely, 'role-physical functioning' (p<0.05), 'vitality' (p<0.05), 'mental health' (p<0.05) and 'bodily pain' (p<0.05) were significantly different between the groups. Comparing the I-QoL sores in the two groups, patients with UI had significantly poorer subscale scores of I-QoL than the controls (p<0.05 for all domains). When women with UI were subdivided into groups of stress and mixed UI, only 2 domains of the SF-36 questionnaire, 'role-physical functioning' (p<0.05) and 'bodily pain' (p<0.05), were significantly different. The mixed UI group had higher scores only on these two domains compared to the stress UI group. In the 'role-physical functioning' domain, there was no significant difference between the mixed UI group and the controls. In 'bodily pain' domain, there was no significant difference between the stress UI group and the controls. The mixed group had the highest scores observed. Patients with mixed UI had significantly lower total scores compared to those with stress UI, including the subscale score of 'avoidance behavior' of the I-QoL. Among eight domains of the SF-36, only 'physical functioning' (r = 0.281, p<0.01) and 'social functioning' (r = 0.239, p<0.05) were weakly correlated with 'psychological impact' of the I-QoL.
Our findings show that the generic QOL instrument is not sensitive measure of QOL in women with UI.
本研究旨在确定一种通用的健康结局工具是否有助于评估患有压力性尿失禁（UI）合并或不合并急迫性尿失禁的女性。
共有109名尿失禁女性和80名对照者参与了本研究。使用医学结局研究36项简短形式一般健康调查（SF-36）和尿失禁生活质量（I-QoL）问卷来测量与健康相关的生活质量（QOL）。
在SF-36问卷的八个领域中，两组之间只有四个领域存在显著差异，即“角色-身体功能”（p<0.05）、“活力”（p<0.05）、“心理健康”（p<0.05）和“身体疼痛”（p<0.05）。比较两组的I-QoL得分，尿失禁患者的I-QoL分量表得分明显低于对照组（所有领域p<0.05）。当将尿失禁女性细分为压力性尿失禁组和混合性尿失禁组时，SF-36问卷中只有两个领域，即“角色-身体功能”（p<0.05）和“身体疼痛”（p<0.05）存在显著差异。与压力性尿失禁组相比，混合性尿失禁组仅在这两个领域得分较高。在“角色-身体功能”领域，混合性尿失禁组与对照组之间无显著差异。在“身体疼痛”领域，压力性尿失禁组与对照组之间无显著差异。混合组的得分最高。与压力性尿失禁患者相比，混合性尿失禁患者的总分显著较低，包括I-QoL的“回避行为”分量表得分。在SF-36的八个领域中，只有“身体功能”（r = 0.281，p<0.01）和“社会功能”（r = 0.239，p<0.05）与I-QoL的“心理影响”呈弱相关。
我们的研究结果表明，通用的生活质量工具对尿失禁女性的生活质量测量不敏感。
