Migliore M, Culotta M
Institute for Interdisciplinary Applications of Physics, National Research Council, Palermo, Italy.
Biosystems. 1998 Sep-Dec;48(1-3):157-63. doi: 10.1016/s0303-2647(98)00061-6.
The voltage dependent ionic conductances and the passive properties of the neural membrane determine how external inputs are processed by the dendritic tree, and define the computational characteristics of neurons. However, what controls these characteristics and how they are implemented at the single neuron level, in such a way that an external input results in the coding of the appropriate output, is essentially unknown. We show here that a slow inactivation of the Na+ channel, involved in the attenuation and/or failure of APs in the dendrites, acts as an active and energy efficient filter of synaptic input, and results in an activity-dependent control of the properties of individual neurons. Thus, the activation or expression of this mechanisms could be an efficient way to selectively modulate the input/output processing properties of dendrites, and could be needed to limit or suppress the onset of a number of pathological brain disorders.
电压依赖性离子电导和神经膜的被动特性决定了树突树如何处理外部输入，并定义了神经元的计算特性。然而，是什么控制这些特性以及它们如何在单个神经元水平上实现，使得外部输入导致适当输出的编码，基本上仍是未知的。我们在此表明，参与树突中动作电位衰减和/或失败的Na+通道的缓慢失活，作为突触输入的一种主动且节能的滤波器，并导致对单个神经元特性的活动依赖性控制。因此，这种机制的激活或表达可能是选择性调节树突输入/输出处理特性的有效方式，并且可能是限制或抑制多种病理性脑部疾病发作所必需的。
