Migliore M, Hoffman D A, Magee J C, Johnston D
National Research Council, Institute of Advanced Diagnostic Methodologies, Palermo, Italy.
J Comput Neurosci. 1999 Jul-Aug;7(1):5-15. doi: 10.1023/a:1008906225285.
Action potentials elicited in the axon actively back-propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre- and postsynaptic activity could help regulate the amplitude of back-propagating action potentials, especially in the distal portion of the dendritic tree.
轴突中引发的动作电位会主动反向传播到树突树中。在此过程中，它们的振幅可受到内部和外部因素的调节。我们使用海马CA1锥体神经元的房室模型来说明这种调节如何取决于：（1）在海马树突中高密度表达的A型钾离子电导的特性；（2）突触激活的相对时间。模拟结果表明，突触前和突触后活动之间的时间关系可能有助于调节反向传播动作电位的振幅，尤其是在树突树的远端部分。
