Scribner D R, Walker J L
Department of Gynecologic Oncology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, 73190, USA.
Gynecol Oncol. 1998 Dec;71(3):458-60. doi: 10.1006/gyno.1998.5174.
A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the mainstay for primary treatment. The role of chemotherapy, radiation therapy, and hormonal therapy is poorly defined. This is a case report of neoadjuvant hormonal therapy which may improve outcomes in patients with endometrial stromal sarcomas. Additional research is needed to define the exact role of these agents.
一名46岁女性被诊断为无法手术切除的低级别子宫内膜间质肉瘤。给予两剂7.5毫克的醋酸亮丙瑞林缓释微球和每日160毫克的甲地孕酮，以控制子宫出血并缩小肿瘤体积。9周后，肿瘤显著缩小，从而能够进行手术切除。全腹子宫切除术加双侧输卵管卵巢切除术是主要的初始治疗方法。化疗、放疗和激素治疗的作用尚不明确。这是一篇关于新辅助激素治疗的病例报告，该治疗可能改善子宫内膜间质肉瘤患者的治疗效果。需要进一步研究来明确这些药物的确切作用。
