Micu D, Mihăilescu E, Cheta D, Olinescu V, Pop A
Med Interne. 1976 Apr-Jun;14(2):103-7.
Leukocyte acid phosphatases were investigated in 146 patients with different chronic diseases. The method of investigation used was that of Kaplow and Burstone slightly modified by the authors in what regards the pH of the incubation medium. Normal or slightly increased scores were observed in the granulocytic series of patients with chronic myeloid leukemia. In patients with rheumatoid arthritis, chronic hepatitis, lupus erythematosus disseminatus and chronic lymphocytic leukemia a moderate enzymatic activity was generally observed in the lymphocyte and more marked in severe forms of disease. A marked increase of the enzyme activity was observed in patients with myeloma. The possibility of a correlation between the intensity of enzyme activity and immunoglobulin formation is discussed.
对146例患有不同慢性疾病的患者进行了白细胞酸性磷酸酶研究。所采用的研究方法是作者对卡普洛和伯尔斯通的方法进行了轻微修改，修改之处在于孵育介质的pH值。在慢性粒细胞白血病患者的粒细胞系列中观察到正常或略有升高的分数。在类风湿性关节炎、慢性肝炎、播散性红斑狼疮和慢性淋巴细胞白血病患者中，淋巴细胞通常表现出中等程度的酶活性，在疾病的严重形式中更为明显。在骨髓瘤患者中观察到酶活性显著增加。讨论了酶活性强度与免疫球蛋白形成之间存在相关性的可能性。
