大鼠脑纹状体中多巴胺含量对麻醉需求的影响：一项体内微透析研究。
Effect of dopamine content in rat brain striatum on anesthetic requirement: an in vivo microdialysis study.
作者信息
Onozawa H, Miyano K, Tanifuji Y
机构信息
Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, Japan.
出版信息
Brain Res. 1999 Jan 30;817(1-2):192-5. doi: 10.1016/s0006-8993(98)01110-x.
This study investigated the changes in anesthetic requirement caused by administration of two different concentrations (0.1 microM and 1. 0 microM/h) of dopamine into the rat striatum. During the measurement of minimum alveolar concentration (MAC), each dopamine solution was continuously injected directly into rat striatum by microdialysis technique. During perfusion of the lower dose, MAC did not change. During the higher dose of dopamine, MAC decreased by approximately 30%.
本研究调查了向大鼠纹状体内注射两种不同浓度（0.1微摩尔/升和1.0微摩尔/升/小时）多巴胺所引起的麻醉需求变化。在测量最低肺泡浓度（MAC）期间，通过微透析技术将每种多巴胺溶液持续直接注射到大鼠纹状体内。在灌注较低剂量时，MAC没有变化。在较高剂量多巴胺灌注期间，MAC下降了约30%。
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