Chieri R A
Arzneimittelforschung. 1976 Apr;26(4b):696-8.
In two pharmacological in vivo tests a comparative study was performed on the spasmolytic and analgesic effects of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin), metamizole and a combination of both active principles in equal dose ratio (1 : 1000). The results demonstrated that pramiverine showed a potent spasmolytic effect which was potentiated by the combination with metamizole, and that the positive analgesic effect of metamizole was fully displayed in the combination with pramiverine, but that for pramiverine alone no analgesic effect was detected.
在两项体内药理学试验中，对4,4-二苯基-N-异丙基环己胺盐酸盐（普拉米维林，西他尔金）、安乃近以及两种活性成分以等剂量比（1:1000）组合后的解痉和镇痛作用进行了对比研究。结果表明，普拉米维林显示出强效解痉作用，与安乃近组合后该作用增强；安乃近与普拉米维林组合时其阳性镇痛作用得到充分发挥，但单独使用普拉米维林时未检测到镇痛作用。
