Morel C J
Arzneimittelforschung. 1976 Apr;26(4b):699-702.
A preventive effect of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine, Sistalgin) was determined on the experimental gastric ulcer in rats. In 14 patients with duodenal ulcers the maximally stimulated gastric secretion was significantly reduced by 50% after pramiverine, which may serve as a reliable criterium for the evaluation of prospective surgical vagotomy. Electromyographic examinations of stomach and duodenum demonstrated the decrease of spontaneous pressure waves in patients and the pressure increases induced by neostigmine. During hypotensive duodenography without the introduction of a probe, pramiverine by a prolonged reduction of motility permits excellent radiological diagnosis in the duodenum and jejunum.
研究了盐酸4,4-二苯基-N-异丙基环己胺（普拉维林，西斯塔金）对大鼠实验性胃溃疡的预防作用。在14例十二指肠溃疡患者中，普拉维林可使最大刺激胃酸分泌显著减少50%，这可作为评估前瞻性手术迷走神经切断术的可靠标准。胃和十二指肠的肌电图检查显示，患者的自发压力波减少，新斯的明诱导的压力增加。在不插入探头的低血压十二指肠造影检查中，普拉维林通过延长运动减少时间，可实现十二指肠和空肠的优良放射学诊断。
