Dite G S, Bell R, Reddihough D S, Bessell C, Brennecke S, Sheedy M
Department of Child Development and Rehabilitation, Royal Children's Hospital, Melbourne, Victoria, Australia.
Aust N Z J Obstet Gynaecol. 1998 Nov;38(4):377-83. doi: 10.1111/j.1479-828x.1998.tb03091.x.
Routinely collected perinatal morbidity data were abstracted for 204 cases of moderate and severe spastic cerebral palsy and 816 matched controls. Separate analyses were conducted for cases with birth-weight > or = 2,500 g and birth-weight < 2,500 g. The presence of a congenital abnormality was an important risk factor for cerebral palsy in both groups and further analyses were conducted after dividing the groups according to presence or absence of a congenital abnormality. In the < 2,500 g group, resuscitation needed was clearly identified as a risk factor for cerebral palsy in the group with no congenital abnormalities (adjusted OR=3.4; 95% CI=1.6-7.5) while in the group with congenital abnormalities, none of the risk factors were clearly associated with an increased risk of cerebral palsy. Among the cases with birth-weight > or = 2,500 g, intrauterine hypoxia/birth asphyxia was clearly associated with an increased risk of cerebral palsy (adjusted OR=18.1; 95% CI=1.8-186) in the group with no congenital abnormalities while in the group with congenital abnormalities, none of the factors were clearly associated with an increased risk of cerebral palsy.
我们提取了204例中重度痉挛型脑瘫患儿及816例匹配对照的常规围产期发病数据。对出生体重≥2500g和出生体重<2500g的病例分别进行分析。先天性异常的存在是两组脑瘫的重要危险因素，根据有无先天性异常对两组进行分组后进一步分析。在出生体重<2500g组中，在无先天性异常的组中，需要复苏被明确确定为脑瘫的危险因素（校正比值比=3.4；95%可信区间=1.6-7.5），而在有先天性异常的组中，没有危险因素与脑瘫风险增加明显相关。在出生体重≥2500g的病例中，在无先天性异常的组中，宫内缺氧/出生窒息与脑瘫风险增加明显相关（校正比值比=18.1；95%可信区间=1.8-186），而在有先天性异常的组中，没有因素与脑瘫风险增加明显相关。
