Hintz S R, Cheong W F, van Houten J P, Stevenson D K, Benaron D A
Department of Pediatrics, Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, California 94304, USA.
Pediatr Res. 1999 Jan;45(1):54-9. doi: 10.1203/00006450-199901000-00009.
Medical optical imaging (MOI) uses light emitted into opaque tissues to determine the interior structure. Previous reports detailed a portable time-of-flight and absorbance system emitting pulses of near infrared light into tissues and measuring the emerging light. Using this system, optical images of phantoms, whole rats, and pathologic neonatal brain specimens have been tomographically reconstructed. We have now modified the existing instrumentation into a clinically relevant headband-based system to be used for optical imaging of structure in the neonatal brain at the bedside. Eight medical optical imaging studies in the neonatal intensive care unit were performed in a blinded clinical comparison of optical images with ultrasound, computed tomography, and magnetic resonance imaging. Optical images were interpreted as correct in six of eight cases, with one error attributed to the age of the clot, and one small clot not seen. In addition, one disagreement with ultrasound, not reported as an error, was found to be the result of a mislabeled ultrasound report rather than because of an inaccurate optical scan. Optical scan correlated well with computed tomography and magnetic resonance imaging findings in one patient. We conclude that light-based imaging using a portable time-of-flight system is feasible and represents an important new noninvasive diagnostic technique, with potential for continuous monitoring of critically ill neonates at risk for intraventricular hemorrhage or stroke. Further studies are now underway to further investigate the functional imaging capabilities of this new diagnostic tool.
医学光学成像（MOI）利用发射到不透明组织中的光来确定内部结构。先前的报告详细介绍了一种便携式飞行时间和吸光度系统，该系统向组织发射近红外光脉冲并测量出射光。利用该系统，已对体模、整只大鼠和病理性新生儿脑标本的光学图像进行了断层重建。我们现在已将现有仪器改装成一种基于头带的临床适用系统，用于在床边对新生儿脑结构进行光学成像。在新生儿重症监护病房进行了八项医学光学成像研究，对光学图像与超声、计算机断层扫描和磁共振成像进行了盲法临床比较。八项病例中有六项光学图像被判定为正确，一项错误归因于血栓的年龄，还有一项小血栓未被发现。此外，发现与超声的一处不一致（未被报告为错误）是超声报告标记错误所致，而非光学扫描不准确。在一名患者中，光学扫描与计算机断层扫描和磁共振成像结果相关性良好。我们得出结论，使用便携式飞行时间系统的基于光的成像可行，是一种重要的新型非侵入性诊断技术，有潜力对有脑室内出血或中风风险的危重新生儿进行连续监测。目前正在进行进一步研究，以进一步探究这种新诊断工具的功能成像能力。
