neoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Department of Neonatology, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Pediatr Res. 2017 Sep;82(3):376-386. doi: 10.1038/pr.2017.107. Epub 2017 May 31.
Over the past 15 years, functional near-infrared spectroscopy (fNIRS) has emerged as a powerful technology for studying the developing brain. Diffuse optical tomography (DOT) is an extension of fNIRS that combines hemodynamic information from dense optical sensor arrays over a wide field of view. Using image reconstruction techniques, DOT can provide images of the hemodynamic correlates to neural function that are comparable to those produced by functional magnetic resonance imaging. This review article explains the principles of DOT, and highlights the growing literature on the use of DOT in the study of healthy development of the infant brain, and the study of novel pathophysiology in infants with brain injury. Current challenges, particularly around instrumentation and image reconstruction, will be discussed, as will the future of this growing field, with particular focus on whole-brain, time-resolved DOT.
在过去的 15 年中，功能近红外光谱（fNIRS）已成为研究发育中大脑的强大技术。漫射光学断层扫描（DOT）是 fNIRS 的扩展，它结合了宽视场密集光学传感器阵列的血液动力学信息。使用图像重建技术，DOT 可以提供与功能磁共振成像相当的神经功能的血液动力学相关性图像。本文综述了 DOT 的原理，并重点介绍了 DOT 在研究婴儿大脑健康发育以及研究脑损伤婴儿新病理生理学方面的应用的不断增加的文献。目前的挑战，特别是仪器和图像重建方面的挑战，以及这个不断发展的领域的未来，将特别关注全脑、时间分辨 DOT。
