Hintz S R, Benaron D A, van Houten J P, Duckworth J L, Liu F W, Spilman S D, Stevenson D K, Cheong W F
Department of Pediatrics, Stanford University School of Medicine, Stanford University, CA, USA.
Photochem Photobiol. 1998 Sep;68(3):361-9.
Conventional brain-imaging modalities may be limited by high cost, difficulty of bedside use, noncontinuous operation, invasiveness or an inability to obtain measurements of tissue function, such as oxygenation during stroke. Our goal was to develop a bedside clinical device able to generate continuous, noninvasive, tomographic images of the brain using low-power nonionizing optical radiation. We modified an existing stage-based time-of-flight optical tomography system to allow imaging of patients under clinical conditions. First, a stationary head-band consisting of thin, flexible optical fibers was constructed. The headband was then calibrated and tested, including an assessment of fiber lengths, the existing system software was modified to collect headband data and to perform simultaneous collection of data and image reconstruction, and the existing hardware was modified to scan optically using this headband. The headband was tested on resin models and allowed for the generation of tomographic images in vitro; the headband was tested on critically ill infants and allowed for optical tomographic images of the neonatal brain to be obtained in vivo.
传统的脑成像方式可能受到高成本、床边使用困难、非连续操作、侵入性或无法获取组织功能测量值（如中风期间的氧合情况）的限制。我们的目标是开发一种床边临床设备，能够使用低功率非电离光辐射生成大脑的连续、无创断层图像。我们对现有的基于阶段的飞行时间光学断层扫描系统进行了改进，以允许在临床条件下对患者进行成像。首先，构建了一个由细的柔性光纤组成的固定头带。然后对头带进行校准和测试，包括对光纤长度的评估，修改现有的系统软件以收集头带数据并同时进行数据收集和图像重建，以及修改现有的硬件以使用该头带进行光学扫描。对头带在树脂模型上进行了测试，并在体外生成了断层图像；对头带在危重新生儿上进行了测试，并在体内获得了新生儿大脑的光学断层图像。
