自由基损伤生物标志物在实验动物和人类中的应用。
Biomarkers of free radical damage applications in experimental animals and in humans.
作者信息
de Zwart L L, Meerman J H, Commandeur J N, Vermeulen N P
机构信息
Leiden-Amsterdam Center for Drug Research, Department of Pharmacochemistry, Vrije Universiteit, The Netherlands.
出版信息
Free Radic Biol Med. 1999 Jan;26(1-2):202-26. doi: 10.1016/s0891-5849(98)00196-8.
Free radical damage is an important factor in many pathological and toxicological processes. Despite extensive research efforts in biomarkers in recent years, yielding promising results in experimental animals, there is still a great need for additional research on the applicability of, especially non-invasive, biomarkers of free radical damage in humans. This review gives an overview of the applications in experimental and human situations of four main groups of products resulting from free radical damage, these include: lipid peroxidation products, isoprostanes, DNA-hydroxylation products and protein hydroxylation products.
自由基损伤是许多病理和毒理过程中的一个重要因素。尽管近年来对生物标志物进行了广泛研究，并在实验动物中取得了有希望的结果，但仍非常需要对自由基损伤生物标志物（尤其是非侵入性生物标志物）在人类中的适用性进行更多研究。本综述概述了自由基损伤产生的四类主要产物在实验和人类情况下的应用，这些产物包括：脂质过氧化产物、异前列腺素、DNA羟基化产物和蛋白质羟基化产物。
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