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在日本患者中，类风湿性关节炎的膝关节和/或髋关节破坏与HLA-DRB1*0405相关。

Knee and/or hip joint destruction in rheumatoid arthritis is associated with HLA-DRB1*0405 in Japanese patients.

作者信息

Wakitani S, Kuwata K, Imoto K, Murata N, Oonishi H, Ochi T

机构信息

Department of Orthopaedic Surgery, Osaka-Minami National Hospital, Kawachinagano, Japan.

出版信息

Clin Rheumatol. 1998;17(6):485-8. doi: 10.1007/BF01451284.

DOI:10.1007/BF01451284
PMID:9890676
Abstract

To determine the prognostic factors for knee and/or hip joint destruction in rheumatoid arthritis (RA) patients, we typed 379 RA patients for HLA-DRB alleles and analysed the antigen frequencies. The DRB10405 antigen frequency in RA patients who underwent total knee replacement and/or total hip replacement was significantly higher than in those who did not have replacements, which meant that DRB10405 was associated with knee and/or hip joint destruction. This finding may be of value for predicting knee and/or hip joint destruction in RA.

摘要

为了确定类风湿关节炎（RA）患者膝关节和/或髋关节破坏的预后因素，我们对379例RA患者进行了HLA - DRB等位基因分型，并分析了抗原频率。接受全膝关节置换和/或全髋关节置换的RA患者中DRB10405抗原频率显著高于未进行置换的患者，这意味着DRB10405与膝关节和/或髋关节破坏有关。这一发现可能对预测RA患者膝关节和/或髋关节破坏具有价值。

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Clin Rheumatol. 1998;17(6):485-8. doi: 10.1007/BF01451284.
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Therapeutic criteria in rheumatoid arthritis.类风湿关节炎的治疗标准
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Elderly-onset rheumatoid arthritis and its association with HLA-DRB1 alleles in Japanese.日本老年发病型类风湿关节炎及其与HLA - DRB1等位基因的关联。
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The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese.日本人群中HLA - DRB1等位基因与类风湿关节炎疾病亚型的关系。
Br J Rheumatol. 1997 Jun;36(6):630-6. doi: 10.1093/rheumatology/36.6.630.
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Ann Rheum Dis. 1994 Sep;53(9):587-92. doi: 10.1136/ard.53.9.587.
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Association between HLA and Japanese patients with rheumatoid arthritis.HLA与日本类风湿性关节炎患者之间的关联。
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The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.美国风湿病协会1987年修订的类风湿关节炎分类标准。
Arthritis Rheum. 1988 Mar;31(3):315-24. doi: 10.1002/art.1780310302.