Yukioka M, Wakitani S, Murata N, Toda Y, Ogawa R, Kaneshige T, Ochi T
Department of Orthopaedic Surgery, Yukioka Hospital, Osaka, Japan.
Br J Rheumatol. 1998 Jan;37(1):98-101. doi: 10.1093/rheumatology/37.1.98.
To assess the association between HLA-DRB1 and elderly-onset rheumatoid arthritis (RA) (EORA) in Japanese people, we analysed the HLA-DRB1 antigen frequencies of EORA patients. The age at onset distribution of 852 Japanese RA patients was analysed, and EORA was defined as an age at onset of 60 yr or older. Among the 852 RA patients, 120 (14.1%) were EORA patients. Their HLA-DRB1 antigen frequencies were assessed for significant deviation from those of the control (n = 652) and adult-onset RA (AORA; disease onset between 16 and 59 yr; n = 732) groups. The Japanese EORA patients were positively associated with DRB1*0101, *0405 and 1502, and the relative risks were 2.7, 1.9 and 2.2, respectively. The frequency of DRB11502 was also significantly higher among the EORA patients than in the AORA patients. The EORA patients showed different trends from the AORA patients in their frequency of HLA-DRB1 alleles, which suggests that EORA may be a different subset from AORA in light of its immunogenetic background.
为评估日本人中HLA - DRB1与老年发病类风湿关节炎（EORA）之间的关联，我们分析了EORA患者的HLA - DRB1抗原频率。分析了852例日本类风湿关节炎患者的发病年龄分布，EORA定义为发病年龄在60岁及以上。在852例类风湿关节炎患者中，120例（14.1%）为EORA患者。评估了他们的HLA - DRB1抗原频率与对照组（n = 652）和成人发病类风湿关节炎（AORA；发病年龄在16至59岁之间；n = 732）组相比是否有显著差异。日本EORA患者与DRB10101、0405和1502呈正相关，相对风险分别为2.7、1.9和2.2。EORA患者中DRB11502的频率也显著高于AORA患者。EORA患者在HLA - DRB1等位基因频率上与AORA患者呈现不同趋势，这表明从免疫遗传背景来看，EORA可能是与AORA不同的亚组。
