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衰竭的心脏是否能量耗尽?

Is the failing heart energy depleted?

作者信息

Katz A M

机构信息

Department of Medicine, University of Connecticut School of Medicine, Farmington, USA.

出版信息

Cardiol Clin. 1998 Nov;16(4):633-44, viii. doi: 10.1016/s0733-8651(05)70040-0.

DOI:10.1016/s0733-8651(05)70040-0
PMID:9891593
Abstract

This article takes three different approaches to the question of whether the failing heart is in an energy-starved state. A brief historical overview introduces the issue and points out problems in both models and methods. Second, current information regarding the energetic state of the failing heart is examined. Finally, the mechanistic and therapeutic implications of a defect in energy production are described.

摘要

本文采用三种不同方法来探讨衰竭心脏是否处于能量匮乏状态这一问题。简要的历史概述介绍了该问题,并指出了模型和方法两方面存在的问题。其次,审视了有关衰竭心脏能量状态的当前信息。最后,阐述了能量产生缺陷的机制及治疗意义。

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1
Is the failing heart energy depleted?衰竭的心脏是否能量耗尽?
Cardiol Clin. 1998 Nov;16(4):633-44, viii. doi: 10.1016/s0733-8651(05)70040-0.
2
Subcellular distribution of phosphagens in isolated perfused rat heart.磷酸原在离体灌注大鼠心脏中的亚细胞分布
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Is the failing heart energy starved? On using chemical energy to support cardiac function.衰竭的心脏能量匮乏吗?关于利用化学能支持心脏功能的探讨。
Circ Res. 2004 Jul 23;95(2):135-45. doi: 10.1161/01.RES.0000137170.41939.d9.
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Bioenergetics of the failing heart.衰竭心脏的生物能量学
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Mitochondrial ATPase and high-energy phosphates in failing hearts.衰竭心脏中的线粒体ATP酶与高能磷酸盐
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The failing heart.
N Engl J Med. 2007 Jun 14;356(24):2545-6; author reply 2546.
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Metabolism of the failing heart.衰竭心脏的代谢
Cardioscience. 1993 Dec;4(4):199-203.
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Energy levels at systole vs. diastole in normal hamster hearts vs. myopathic hamster hearts.正常仓鼠心脏与患心肌病仓鼠心脏在收缩期和舒张期的能量水平。
Circ Res. 1983 Dec;53(6):759-66. doi: 10.1161/01.res.53.6.759.
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Effects of ischemia on function and metabolism of the isolated working rat heart.缺血对离体工作大鼠心脏功能和代谢的影响。
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[Heart failure - can be treated by affecting cardiac metabolism?].[心力衰竭——能否通过影响心脏代谢来治疗?]
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