Murín Ján, Pernický Miroslav, Kiňová Soňa
Vnitr Lek. 2014 May-Jun;60(5-6):437-41.
Chronic heart failure is a disease of epidemic extent and has a high mortality and morbidity. Etiology is multifactorial, but the issue is that heart does not have "enough fuel" to produce energy for its work or available fuel can´t be properly utilized. Components of cardiac energy metabolism are substrate utilization, oxidative phosphorylation and ATP (adenosine triphosphate) transfer and utilization. The aim of article is to present the function of heart metabolism and how "metabolic dysfunction" contributes to heart failure. Perhaps, drug effect on heart metabolism is an approach to treatment of chronic heart failure.
慢性心力衰竭是一种广泛流行的疾病，具有较高的死亡率和发病率。病因是多因素的，但问题在于心脏没有“足够的燃料”来产生工作所需的能量，或者可用燃料无法得到恰当利用。心脏能量代谢的组成部分包括底物利用、氧化磷酸化以及三磷酸腺苷（ATP）的转运和利用。本文的目的是阐述心脏代谢的功能以及“代谢功能障碍”如何导致心力衰竭。或许，药物对心脏代谢的作用是治疗慢性心力衰竭的一种方法。
