Kourtópoulos H, Holm S E
Neuropadiatrie. 1976 Aug;7(3):356-61. doi: 10.1055/s-0028-1091636.
A 9-months old patient with a ventricular shunt due to hydrocephalus was treated with intraventricular administration of 5-FC due to Candida ventriculitis with satisfactory clinical response. The intraventricular dose given was 5 mg twice daily for 14 days. The same patient was treated four months later with combined peroral and intraventricular administration of 5-FC also with good clinical response. On both occasions there was no evidence of drug toxicity. The peroral dose given was 100 mg/kg bodyweight/day divided in four doses. A few CSF and serum samples were taken to estimate the concentration of 5-FC. The local installation of 5-FC in an isolated ventriculitis seems to be of special beneficial value whereas fungal septicaemia with ventriculitis needs combination of peroral and intraventricular administration. No increase in resistance against 5-FC could be registered.
一名因脑积水接受脑室分流术的9个月大患者，因念珠菌性脑室炎接受脑室内给予5-氟胞嘧啶（5-FC）治疗，临床反应良好。脑室内给药剂量为每日两次，每次5毫克，共14天。该患者在四个月后再次接受治疗，采用口服和脑室内联合给予5-FC，临床反应同样良好。两次治疗均未出现药物毒性迹象。口服剂量为100毫克/千克体重/天，分四次服用。采集了一些脑脊液和血清样本以估算5-FC的浓度。在单纯性脑室炎中局部应用5-FC似乎具有特殊的有益价值，而伴有脑室炎的真菌败血症则需要口服和脑室内联合给药。未发现对5-FC的耐药性增加。
