Chapman R, Sidrauski C, Walter P
Howard Hughes Medical Institute, University of California, San Francisco 94143-0448, USA.
Annu Rev Cell Dev Biol. 1998;14:459-85. doi: 10.1146/annurev.cellbio.14.1.459.
Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR). Recent work has shown that this signaling pathway utilizes several novel mechanisms, including translational attenuation and a regulated mRNA splicing step. In this review we aim to integrate these recent advances with current knowledge about maintenance of ER composition and abundance.
细胞通过增加编码内质网（ER）驻留蛋白的基因转录来应对内质网中未折叠蛋白的积累。信息通过一种称为未折叠蛋白反应（UPR）的细胞内信号通路从内质网腔传递到细胞核。最近的研究表明，该信号通路利用了几种新机制，包括翻译衰减和一个受调控的mRNA剪接步骤。在这篇综述中，我们旨在将这些最新进展与当前关于内质网组成和丰度维持的知识相结合。
