Bivalacqua T J, Dalal A, Lambert D G, Champion H C, Kadowitz P J
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S98-100.
The effects of candesartan (30 microg/kg i.v.) and PD123319 (10 mg/kg i.v.) on changes in systemic arterial pressure in response to angiotensin II (AngII) were investigated in the anesthetized mouse. Intravenous injections of AngII caused dose-related increases in systemic arterial pressure. Pressor responses to AngII were attenuated by candesartan but were not altered by PD123319. Neither candesartan nor PD123319 had a significant effect on baseline systemic arterial pressure or on the increase in arterial pressure in response to norepinephrine. The present results suggest that increases in systemic arterial pressure in response to AngII in the anesthetized mouse are mediated by AT1 receptors and that AT2 receptors do not modulate the pressor response to AngII.
在麻醉小鼠中研究了坎地沙坦（静脉注射30微克/千克）和PD123319（静脉注射10毫克/千克）对血管紧张素II（AngII）引起的全身动脉压变化的影响。静脉注射AngII导致全身动脉压呈剂量相关增加。坎地沙坦减弱了对AngII的升压反应，但PD123319未改变该反应。坎地沙坦和PD123319对基线全身动脉压或对去甲肾上腺素引起的动脉压升高均无显著影响。目前的结果表明，麻醉小鼠中对AngII的全身动脉压升高是由AT1受体介导的，且AT2受体不调节对AngII的升压反应。
