Foray S, Pailloud F, Thouvenot D, Floret D, Aymard M, Lina B
Laboratoire de Virologie, Centre National de Référence des Entérovirus et de l'Hépatite A, Lyon, France.
J Med Virol. 1999 Feb;57(2):193-7.
In a prospective comparative study, the use of combined analysis of upper respiratory tract swab samples and cerebrospinal fluid (CSF) samples was assessed to improve the detection rate of enteroviral meningitis in children. An enterovirus was detected in 32% of patients with aseptic meningitis when testing CSF samples alone compared with 71.5% when combining CSF and respiratory tract findings. An enterovirus was detected in 17% of respiratory tract samples in an age- and sex-matched control group without meningitis. Thus, combining the examination of upper respiratory tract with CSF findings may improve the detection rate of enteroviral meningitis. Upper respiratory tract samples should be included in the diagnosis scheme to differentiate benign enteroviral meningitis from other life-threatening infections of the central nervous system.
在一项前瞻性对照研究中，评估了联合分析上呼吸道拭子样本和脑脊液（CSF）样本对提高儿童肠道病毒性脑膜炎检出率的作用。单独检测脑脊液样本时，32%的无菌性脑膜炎患者检测到肠道病毒，而联合脑脊液和呼吸道检测结果时，这一比例为71.5%。在无脑膜炎的年龄和性别匹配对照组中，17%的呼吸道样本检测到肠道病毒。因此，将上呼吸道检查与脑脊液检测结果相结合可能提高肠道病毒性脑膜炎的检出率。诊断方案应包括上呼吸道样本检测，以鉴别良性肠道病毒性脑膜炎与其他危及生命的中枢神经系统感染。
