Chomel J-J, Antona D, Thouvenot D, Lina B
National Reference Centre for Enteroviruses, Laboratoire de Virologie, Centre Hospitalo Universitaire-Lyon, Domaine Rockefeller, 8, Avenue Rockefeller, 69373, Lyon Cedex 08, France.
Eur J Clin Microbiol Infect Dis. 2003 Mar;22(3):191-3. doi: 10.1007/s10096-003-0896-4. Epub 2003 Mar 4.
During the year 2000 in the Rhône-Alpes region of France, 559 cases of aseptic meningitis due to enterovirus infection were recorded (approximate incidence, 10 cases per 100,000 population compared with a mean of 0.3 cases during endemic years in this region; P<0.001). Cerebrospinal fluid samples were collected from all 559 patients and processed for enterovirus RNA detection using a reverse transcriptase polymerase chain reaction assay only. In addition to the cerebrospinal fluid samples, 40 stool and 76 throat samples were collected from 116 patients (20.7% of cases); the following three enterovirus serotypes were isolated from the stool and throat samples only: ECHOvirus 13 (48/116; 41.3%), ECHOvirus 30 (44/116;37.9%) and ECHOvirus 6 (24/116, 20.7%). This is the first report that demonstrates the involvement of three different ECHOvirus serotypes, particularly ECHOvirus 13, in an outbreak of aseptic meningitis, in the French Rhône-Alpes region.
2000年，在法国罗纳-阿尔卑斯地区，共记录了559例由肠道病毒感染引起的无菌性脑膜炎病例（发病率约为每10万人中有10例，而该地区在流行年份的平均发病率为每10万人中有0.3例；P<0.001）。从所有559例患者身上采集了脑脊液样本，仅使用逆转录聚合酶链反应检测法对样本进行肠道病毒RNA检测。除脑脊液样本外，还从116例患者（占病例总数的20.7%）身上采集了40份粪便样本和76份咽喉样本；仅从粪便和咽喉样本中分离出了以下三种肠道病毒血清型：埃可病毒13型（48/116；41.3%）、埃可病毒30型（44/116；37.9%）和埃可病毒6型（24/116，20.7%）。这是首份证明三种不同的埃可病毒血清型，尤其是埃可病毒13型，在法国罗纳-阿尔卑斯地区无菌性脑膜炎暴发中起作用的报告。
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