HLA - B27阳性的急性前葡萄膜炎和强直性脊柱炎患者对肺炎克雷伯菌荚膜多糖的体液免疫反应。

Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis.

作者信息

Sahly H, Podschun R, Kekow J, Nölle B, Gross W L, Ullmann U

机构信息

Department of Medical Microbiology and Virology, University of Kiel, Germany.

出版信息

Autoimmunity. 1998;28(4):209-15. doi: 10.3109/08916939808995368.

DOI:10.3109/08916939808995368

PMID:9892502

Abstract

Klebsiella is suggested to trigger ankylosing spondylitis (AS) and acute anterior uveitis (AAU) in HLA-B27-positive individuals. Previous investigations showed an increased antibody response to the Klebsiella capsular types K26, K36, and K50 in sera from HLA-B27-positive AS patients. In the present study the prevalence and titers of antibodies against Klebsiella capsular antigens were measured by means of an ELISA in 32 sera from HLA-B27-positive AAU patients either with (n = 10) or without AS (n = 22) and compared with sera from HLA-B27-negative AS-patients (n = 13). Sera from either HLA-B27-positive (n = 45) or negative (n = 40) healthy individuals served as control. Sera from HLA-B27-positive AAU with or without AS showed significantly higher antibody prevalence and IgG-titers against capsular antigens of the Klebsiella serotypes K26, K36, and K50 when compared with sera from HLA-B27-negative AS patients or with healthy controls. These results might be taken to indicate the predominance of these serotypes in the HLA-B27-associated AS and AAU.

摘要

肺炎克雷伯菌被认为可在 HLA - B27 阳性个体中引发强直性脊柱炎（AS）和急性前葡萄膜炎（AAU）。先前的研究表明，HLA - B27 阳性 AS 患者血清中对肺炎克雷伯菌荚膜类型 K26、K36 和 K50 的抗体反应增强。在本研究中，通过酶联免疫吸附测定法（ELISA）检测了 32 份来自 HLA - B27 阳性 AAU 患者的血清中抗肺炎克雷伯菌荚膜抗原的患病率和滴度，这些患者中有 AS 的 10 例，无 AS 的 22 例，并与 HLA - B27 阴性 AS 患者（13 例）的血清进行比较。来自 HLA - B27 阳性（45 例）或阴性（40 例）健康个体的血清作为对照。与 HLA - B27 阴性 AS 患者的血清或健康对照相比，HLA - B27 阳性有或无 AS 的 AAU 患者血清中针对肺炎克雷伯菌血清型 K26、K36 和 K50 荚膜抗原的抗体患病率和 IgG 滴度显著更高。这些结果可能表明这些血清型在 HLA - B27 相关的 AS 和 AAU 中占主导地位。