急性前葡萄膜炎中可能存在的强直性脊柱炎。

Possible ankylosing spondylitis in acute anterior uveitis.

作者信息

Linssen A, Dekker-Saeys A J, Dandrieu M R, Christiaans B J, Baarsma G S, Tjoa S T, de Jong P T, Kijlstra A, Feltkamp T E

出版信息

Br J Rheumatol. 1983 Nov;22(4 Suppl 2):137-43. doi: 10.1093/rheumatology/xxii.suppl_2.137.

DOI:10.1093/rheumatology/xxii.suppl_2.137

PMID:6606466

Abstract

HLA-B27 typing of 103 acute anterior uveitis (AAU) patients showed that 49 (48%) were positive for this antigen. Of these HLA-B27 positive AAU patients, 27 (55%) had ankylosing spondylitis (AS) according to the New York criteria. The 22 HLA-B27 positive AAU patients without AS, however, also showed symptoms and signs of AS. Seventeen (77%) of these 22 HLA-B27 positive AS negative AAU patients fulfilled a set of criteria for classification as possible AS. In the group of 54 HLA-B27 negative AAU patients, only two patients (4%) had AS. Of the remaining 52 patients only seven (13%) had possible AS. Of the 21 patients having posterior uveitis (PU) none was HLA-B27 positive nor met the criteria for AS or possible AS. These findings indicate a strong relationship between AAU, AS or possible AS and HLA-B27 and suggest that HLA-B27 typing in AAU patients is important for early diagnosis of AS.

摘要

对103例急性前葡萄膜炎（AAU）患者进行HLA - B27分型，结果显示49例（48%）该抗原呈阳性。在这些HLA - B27阳性的AAU患者中，根据纽约标准，27例（55%）患有强直性脊柱炎（AS）。然而，22例HLA - B27阳性但无AS的AAU患者也表现出AS的症状和体征。这22例HLA - B27阳性但AS阴性的AAU患者中有17例（77%）符合可能为AS的一组分类标准。在54例HLA - B27阴性的AAU患者中，仅有2例（4%）患有AS。其余52例患者中只有7例（13%）可能患有AS。在21例患有后葡萄膜炎（PU）的患者中，无一例HLA - B27呈阳性，也不符合AS或可能为AS的标准。这些发现表明AAU、AS或可能为AS与HLA - B27之间存在密切关系，并提示对AAU患者进行HLA - B27分型对AS的早期诊断很重要。