Muck B R, Trotnow S, Egger H, Hommel G
Arch Gynakol. 1976;221(1):83-91. doi: 10.1007/BF00667684.
Breast diseases in 792 women were studied by biopsy and histological evaluation. In all subjects glucose tolerance was examined by OGTT (100 g glucose). The diabetes frequency of 22% in 326 women with breast cancer was compared with the frequency in women with fibroadenoma (n = 101), papilloma (n = 80), fibrocystic disease (n = 107), lipoma, granuloma, fibrosis (n = 88), papilloma with proliferation (n = 32), mastopathy with proliferation (n = 33) and carcinoma in situ lobulare (n = 11). The statistical evaluation was done with an electronic data processing system. We used matched pairs according to age, height and weight. Diabetogenic factors like age and overweight were thus allowed for. These comparative statistics showed a frequency of diabetes twice or three times higher in women with breast cancer. This result cannot be regarded as a consequence of age, overweight and menopause. In groups with fibroadenoma, fibrocystic disease and lipoma, we found glucose tolerance in 1-3%, whereas the group with proliferation (including carcinoma in situ) showed an incidence of 7%. The remarkably high incidence rate of 14% in women with papilloma can be explained by the higher age and the more frequent obesity in this collective.
通过活检和组织学评估对792名女性的乳腺疾病进行了研究。对所有受试者均采用口服葡萄糖耐量试验（OGTT，100g葡萄糖）检测糖耐量。将326例乳腺癌女性患者中22%的糖尿病发生率与纤维腺瘤（n = 101）、乳头状瘤（n = 80）、纤维囊性疾病（n = 107）、脂肪瘤、肉芽肿、纤维化（n = 88）、伴有增生的乳头状瘤（n = 32）、伴有增生的乳腺病（n = 33）和小叶原位癌（n = 11）女性患者的发生率进行了比较。采用电子数据处理系统进行统计学评估。我们根据年龄、身高和体重进行配对。这样就考虑到了年龄和超重等致糖尿病因素。这些比较性统计数据显示，乳腺癌女性患者的糖尿病发生率高出两到三倍。这一结果不能被视为年龄、超重和绝经的结果。在纤维腺瘤、纤维囊性疾病和脂肪瘤组中，我们发现糖耐量异常的发生率为1% - 3%，而伴有增生（包括原位癌）的组发生率为7%。乳头状瘤女性患者中14%的显著高发生率可以用该群体中较高的年龄和更频繁的肥胖来解释。
