Allegra J C, Lippman M E, Green L, Barlock A, Simon R, Thompson E B, Huff K K, Griffin W
Cancer. 1979 Jul;44(1):228-31. doi: 10.1002/1097-0142(197907)44:1<228::aid-cncr2820440137>3.0.co;2-0.
Tissue specimens from 55 female patients with benign breast disease were assayed for estrogen receptor. Twenty-one of 55 patients (38%) had tumors which contained significant amounts of estrogen receptor (greater than 10 femtomoles/mg protein). Fibroadenomas possessed estrogen receptor more frequently than fibrocystic disease or other benign breast tumors. Estrogen receptor positivity did not correlate with laterality of the tumor; location or size of the largest nodule. Patients with estrogen receptor positive tumors had a mean age of 26.9 years compared to 36.4 years for patients with estrogen receptor negative tumors (p less than 0.01). Twenty of 46 (43%) premenopausal patients had benign tumors which were estrogen receptor positive compared to zero of 8 postmenopausal patients (p less than 0.05).
对55例患有良性乳腺疾病的女性患者的组织标本进行雌激素受体检测。55例患者中有21例（38%）的肿瘤含有大量雌激素受体（大于10飞摩尔/毫克蛋白质）。纤维腺瘤比纤维囊性疾病或其他良性乳腺肿瘤更频繁地拥有雌激素受体。雌激素受体阳性与肿瘤的侧别、最大结节的位置或大小无关。雌激素受体阳性肿瘤患者的平均年龄为26.9岁，而雌激素受体阴性肿瘤患者的平均年龄为36.4岁（p<0.01）。46例绝经前患者中有20例（43%）的良性肿瘤为雌激素受体阳性，而8例绝经后患者中无一例阳性（p<0.05）。
