Frequency of application of topical corticosteroids: an overview.

The frequency of application of topical corticosteroids has remained an unresolved issue through the decades with most textbooks and physicians recommending multiple daily use. This review focuses on the rationale of once daily application of corticoids as an effective treatment in some patients. Dermatopharmacokinetic data relevant to the dosage and frequency of application of topical corticoids are discussed. Clinical trials on the efficacy of once daily vs. twice daily applications are evaluated.