Szczepanik M, Nowak B, Askenase P W, Ptak W
Jagiellonian University, College of Medicine, Department of Immunology, Cracow, Poland.
Immunology. 1998 Dec;95(4):612-7. doi: 10.1046/j.1365-2567.1998.00642.x.
The role of gamma delta T cells in immunoregulation is largely unknown. In the current study we noted that gamma delta T cells play a positive role in the humoral response. These positively acting gamma delta T cells are required for the successful adoptive cell transfer of the humoral response, as well as for in vitro generation of plaque-forming cells (PFC). The presented results show that gammadelta T cells cause an increase in interleukin-10 (IL-10) production, which partly elucidates the mechanism of action of these cells. However, experiments with cell culture inserts strongly suggest that direct cell-cell contact between immune and gamma delta H-2-compatible regulatory T cells is critical to the exertion of the positive immunoregulatory function of gamma delta cells. The mechanism of cross-talk between these two cell populations is still not clear but we regard as most likely that the positively acting gamma delta T cells may interact with a complex of heat-shock protein-non-polymorphic MHC (IB) on the surface of T helper type 2 and/or B cells. This could provide, by direct cell-cell contact, the cognate recognition between gamma delta T-cell receptors and heat-shock protein-MHC that leads to positive internal signalling in the immune cells.
γδ T细胞在免疫调节中的作用很大程度上尚不清楚。在当前研究中，我们注意到γδ T细胞在体液反应中发挥积极作用。这些起积极作用的γδ T细胞对于体液反应的成功过继性细胞转移以及体外产生噬斑形成细胞（PFC）是必需的。所呈现的结果表明，γδ T细胞会导致白细胞介素-10（IL-10）产生增加，这部分阐明了这些细胞的作用机制。然而，使用细胞培养插入物进行的实验强烈表明，免疫细胞与γδ H-2相容调节性T细胞之间的直接细胞间接触对于γδ细胞发挥积极免疫调节功能至关重要。这两种细胞群体之间的相互作用机制仍不清楚，但我们认为最有可能的是，起积极作用的γδ T细胞可能与2型辅助性T细胞和/或B细胞表面的热休克蛋白 - 非多态性MHC（IB）复合物相互作用。通过直接细胞间接触，这可以提供γδ T细胞受体与热休克蛋白 - MHC之间的同源识别，从而在免疫细胞中引发积极的内部信号传导。
